Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

The tryptophan (TRP) to kynurenine (KYN) metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway – driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and TRP-2,3-...

Descripción completa

Detalles Bibliográficos
Autores principales: Platten, Michael, von Knebel Doeberitz, Nikolaus, Oezen, Iris, Wick, Wolfgang, Ochs, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290671/
https://www.ncbi.nlm.nih.gov/pubmed/25628622
http://dx.doi.org/10.3389/fimmu.2014.00673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290671/
https://www.ncbi.nlm.nih.gov/pubmed/25628622
http://dx.doi.org/10.3389/fimmu.2014.00673

Ejemplares similares