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Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

The tryptophan (TRP) to kynurenine (KYN) metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway – driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and TRP-2,3-...

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Detalles Bibliográficos
Autores principales:	Platten, Michael, von Knebel Doeberitz, Nikolaus, Oezen, Iris, Wick, Wolfgang, Ochs, Katharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290671/ https://www.ncbi.nlm.nih.gov/pubmed/25628622 http://dx.doi.org/10.3389/fimmu.2014.00673

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