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Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation
BACKGROUND: Recent studies have demonstrated a relationship between fructose consumption and risk of developing metabolic syndrome. Mechanisms by which dietary fructose mediates metabolic changes are poorly understood. This study compared the effects of fructose, glucose and sucrose consumption on p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290803/ https://www.ncbi.nlm.nih.gov/pubmed/25515398 http://dx.doi.org/10.1186/1476-511X-13-195 |
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author | Jameel, Faizan Phang, Melinda Wood, Lisa G Garg, Manohar L |
author_facet | Jameel, Faizan Phang, Melinda Wood, Lisa G Garg, Manohar L |
author_sort | Jameel, Faizan |
collection | PubMed |
description | BACKGROUND: Recent studies have demonstrated a relationship between fructose consumption and risk of developing metabolic syndrome. Mechanisms by which dietary fructose mediates metabolic changes are poorly understood. This study compared the effects of fructose, glucose and sucrose consumption on post-postprandial lipemia and low grade inflammation measured as hs-CRP. METHODS: This was a randomized, single blinded, cross-over trial involving healthy subjects (n = 14). After an overnight fast, participants were given one of 3 different isocaloric drinks, containing 50 g of either fructose or glucose or sucrose dissolved in water. Blood samples were collected at baseline, 30, 60 and 120 minutes post intervention for the analysis of blood lipids, glucose, insulin and high sensitivity C-reactive protein (hs-CRP). RESULTS: Glucose and sucrose supplementation initially resulted in a significant increase in glucose and insulin levels compared to fructose supplementation and returned to near baseline values within 2 hours. Change in plasma cholesterol, LDL and HDL-cholesterol (measured as area under curve, AUC) was significantly higher when participants consumed fructose compared with glucose or sucrose (P < 0.05). AUC for plasma triglyceride levels however remained unchanged regardless of the dietary intervention. Change in AUC for hs-CRP was also significantly higher in subjects consuming fructose compared with those consuming glucose (P < 0.05), but not sucrose (P = 0.07). CONCLUSION: This study demonstrates that fructose as a sole source of energy modulates plasma lipids and hsCRP levels in healthy individuals. The significance of increase in HDL-cholesterol with a concurrent increase in LDL-cholesterol and elevated hs-CRP levels remains to be delineated when considering health effects of feeding fructose-rich diets. REGISTRATION NUMBER FOR CLINICAL TRIALS: ACTRN12614000431628 |
format | Online Article Text |
id | pubmed-4290803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42908032015-01-13 Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation Jameel, Faizan Phang, Melinda Wood, Lisa G Garg, Manohar L Lipids Health Dis Research BACKGROUND: Recent studies have demonstrated a relationship between fructose consumption and risk of developing metabolic syndrome. Mechanisms by which dietary fructose mediates metabolic changes are poorly understood. This study compared the effects of fructose, glucose and sucrose consumption on post-postprandial lipemia and low grade inflammation measured as hs-CRP. METHODS: This was a randomized, single blinded, cross-over trial involving healthy subjects (n = 14). After an overnight fast, participants were given one of 3 different isocaloric drinks, containing 50 g of either fructose or glucose or sucrose dissolved in water. Blood samples were collected at baseline, 30, 60 and 120 minutes post intervention for the analysis of blood lipids, glucose, insulin and high sensitivity C-reactive protein (hs-CRP). RESULTS: Glucose and sucrose supplementation initially resulted in a significant increase in glucose and insulin levels compared to fructose supplementation and returned to near baseline values within 2 hours. Change in plasma cholesterol, LDL and HDL-cholesterol (measured as area under curve, AUC) was significantly higher when participants consumed fructose compared with glucose or sucrose (P < 0.05). AUC for plasma triglyceride levels however remained unchanged regardless of the dietary intervention. Change in AUC for hs-CRP was also significantly higher in subjects consuming fructose compared with those consuming glucose (P < 0.05), but not sucrose (P = 0.07). CONCLUSION: This study demonstrates that fructose as a sole source of energy modulates plasma lipids and hsCRP levels in healthy individuals. The significance of increase in HDL-cholesterol with a concurrent increase in LDL-cholesterol and elevated hs-CRP levels remains to be delineated when considering health effects of feeding fructose-rich diets. REGISTRATION NUMBER FOR CLINICAL TRIALS: ACTRN12614000431628 BioMed Central 2014-12-16 /pmc/articles/PMC4290803/ /pubmed/25515398 http://dx.doi.org/10.1186/1476-511X-13-195 Text en © Jameel et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Jameel, Faizan Phang, Melinda Wood, Lisa G Garg, Manohar L Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation |
title | Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation |
title_full | Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation |
title_fullStr | Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation |
title_full_unstemmed | Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation |
title_short | Acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation |
title_sort | acute effects of feeding fructose, glucose and sucrose on blood lipid levels and systemic inflammation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290803/ https://www.ncbi.nlm.nih.gov/pubmed/25515398 http://dx.doi.org/10.1186/1476-511X-13-195 |
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