Single-Molecule FRET Reveals Hidden Complexity in a Protein Energy Landscape

Here, using single-molecule FRET, we reveal previously hidden conformations of the ankyrin-repeat domain of AnkyrinR, a giant adaptor molecule that anchors integral membrane proteins to the spectrin-actin cytoskeleton through simultaneous binding of multiple partner proteins. We show that the ankyri...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsytlonok, Maksym, Ibrahim, Shehu M., Rowling, Pamela J.E., Xu, Wenshu, Ruedas-Rama, Maria J., Orte, Angel, Klenerman, David, Itzhaki, Laura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291146/
https://www.ncbi.nlm.nih.gov/pubmed/25565106
http://dx.doi.org/10.1016/j.str.2014.10.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291146/
https://www.ncbi.nlm.nih.gov/pubmed/25565106
http://dx.doi.org/10.1016/j.str.2014.10.023

Ejemplares similares