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Single-Molecule FRET Reveals Hidden Complexity in a Protein Energy Landscape

Here, using single-molecule FRET, we reveal previously hidden conformations of the ankyrin-repeat domain of AnkyrinR, a giant adaptor molecule that anchors integral membrane proteins to the spectrin-actin cytoskeleton through simultaneous binding of multiple partner proteins. We show that the ankyri...

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Detalles Bibliográficos
Autores principales:	Tsytlonok, Maksym, Ibrahim, Shehu M., Rowling, Pamela J.E., Xu, Wenshu, Ruedas-Rama, Maria J., Orte, Angel, Klenerman, David, Itzhaki, Laura S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Short Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291146/ https://www.ncbi.nlm.nih.gov/pubmed/25565106 http://dx.doi.org/10.1016/j.str.2014.10.023

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