Electron Microscopy in Rat Brain Slices Reveals Rapid Accumulation of Cisplatin on Ribosomes and Other Cellular Components Only in Glia

Cisplatin is a widely used, effective anticancer drug. Its use, however, is associated with several side effects including nephrotoxicity and neurotoxicity. It is known that cisplatin is accumulated in cells by the organic cation transport system and reacts with nucleotides, damaging them, but the p...

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Detalles Bibliográficos
Autores principales: Zueva, Lidia, Rivera, Yomarie, Kucheryavykh, Lilia, Skatchkov, Serguei N., Eaton, Misty J., Sanabria, Priscila, Inyushin, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291194/
https://www.ncbi.nlm.nih.gov/pubmed/25610648
http://dx.doi.org/10.1155/2014/174039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291194/
https://www.ncbi.nlm.nih.gov/pubmed/25610648
http://dx.doi.org/10.1155/2014/174039

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