Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

Neutral sphingomyelinase (nSMase) activation in response to environmental stress or inflammatory cytokine stimuli generates the second messenger ceramide, which mediates the stress-induced apoptosis. However, the signaling pathways and activation mechanism underlying this process have yet to be eluc...

Descripción completa

Detalles Bibliográficos
Autores principales: Yabu, T, Shiba, H, Shibasaki, Y, Nakanishi, T, Imamura, S, Touhata, K, Yamashita, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291487/
https://www.ncbi.nlm.nih.gov/pubmed/25168245
http://dx.doi.org/10.1038/cdd.2014.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291487/
https://www.ncbi.nlm.nih.gov/pubmed/25168245
http://dx.doi.org/10.1038/cdd.2014.128

Ejemplares similares