Cargando…

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

Neutral sphingomyelinase (nSMase) activation in response to environmental stress or inflammatory cytokine stimuli generates the second messenger ceramide, which mediates the stress-induced apoptosis. However, the signaling pathways and activation mechanism underlying this process have yet to be eluc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yabu, T, Shiba, H, Shibasaki, Y, Nakanishi, T, Imamura, S, Touhata, K, Yamashita, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291487/ https://www.ncbi.nlm.nih.gov/pubmed/25168245 http://dx.doi.org/10.1038/cdd.2014.128

Ejemplares similares

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer’s disease
por: Tallon, Carolyn, et al.
Publicado: (2023)

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model
por: Tallon, Carolyn, et al.
Publicado: (2023)

Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi
por: Gu, LiZe, et al.
Publicado: (2013)

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice
por: Tallon, Carolyn, et al.
Publicado: (2022)

Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia
por: Sackmann, Valerie, et al.
Publicado: (2019)

Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice
por: Huang, Meixiang, et al.
Publicado: (2023)

The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures
por: Houston, D. A., et al.
Publicado: (2016)

The nSMase2/Smpd3 gene modulates the severity of muscular dystrophy and the emotional stress response in mdx mice
por: Matsuzaka, Yasunari, et al.
Publicado: (2020)

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis
por: Kosaka, Nobuyoshi, et al.
Publicado: (2013)

nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe(−/−) Mice
por: Lallemand, Tom, et al.
Publicado: (2018)

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model
por: Zhu, Chunni, et al.
Publicado: (2021)

Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model
por: Zhu, Chunni, et al.
Publicado: (2021)

Therapeutic Application of Extracellular Vesicles-Capsulated Adeno-Associated Virus Vector via nSMase2/Smpd3, Satellite, and Immune Cells in Duchenne Muscular Dystrophy
por: Matsuzaka, Yasunari, et al.
Publicado: (2022)

Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro
por: Lang, Jennifer K., et al.
Publicado: (2016)

Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation
por: Álvarez-Fernández, Hadrián, et al.
Publicado: (2022)

Induction of Autophagy by Amino Acid Starvation in Fish Cells
por: Yabu, Takeshi, et al.
Publicado: (2012)

Alpha‐mangostin improves endothelial dysfunction in db/db mice through inhibition of aSMase/ceramide pathway
por: Jiang, Meng, et al.
Publicado: (2021)

Transcriptome analysis of intestine from alk-SMase knockout mice reveals the effect of alk-SMase
por: Zhu, Jiang, et al.
Publicado: (2022)

Correction: Transcriptome analysis of intestine from alk-SMase knockout mice reveals the effect of alk-SMase
por: Zhu, Jiang, et al.
Publicado: (2022)

Selenoneine, a Novel Selenium-Containing Compound, Mediates Detoxification Mechanisms against Methylmercury Accumulation and Toxicity in Zebrafish Embryo
por: Yamashita, Michiaki, et al.
Publicado: (2013)

Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-α, and JNK
por: Lew, Bark-Lynn, et al.
Publicado: (2006)

JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis
por: Tomlinson, V, et al.
Publicado: (2010)

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation
por: Haimovitz-Friedman, Adriana, et al.
Publicado: (1997)

Transcriptome analysis alk-SMase knockout mice reveals the effect of alkaline sphingomyelinase on liver
por: Zhu, Jiang, et al.
Publicado: (2022)

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
Publicado: (1994)

Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer
por: Hwang, Woo Yeon, et al.
Publicado: (2021)

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
por: Huntwork-Rodriguez, Sarah, et al.
Publicado: (2013)

Probiotic Sonicates Selectively Induce Mucosal Immune Cells Apoptosis through Ceramide Generation via Neutral Sphingomyelinase
por: Angulo, Sandra, et al.
Publicado: (2011)

Ceramide: a signal for apoptosis or mitogenesis?
Publicado: (1995)

Correction: Probiotic Sonicates Selectively Induce Mucosal Immune Cells Apoptosis through Ceramide Generation via Neutral Sphingomyelinase
Publicado: (2022)

Peculiar Expression of CD3-Epsilon in Kidney of Ginbuna Crucian Carp
por: Miyazawa, Ryuichiro, et al.
Publicado: (2018)

Sphingomyelinase D Activity in Sicarius tropicus Venom: Toxic Potential and Clues to the Evolution of SMases D in the Sicariidae Family
por: Lopes, Priscila Hess, et al.
Publicado: (2021)

Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide
por: Paul, Manoj, et al.
Publicado: (2015)

The Targeting of Plasmalemmal Ceramide to Mitochondria during Apoptosis
por: Babiychuk, Eduard B., et al.
Publicado: (2011)

The Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces Autophagy and Apoptosis in Human Melanoma via AMPK/JNK Phosphorylation
por: Kang, Soouk, et al.
Publicado: (2014)

Alteration of hemoglobin ß gene expression in mucosal tissues of Japanese flounder, Paralichthys olivaceus, in response to heat stress, Edwardsiella piscicida infection, and immunostimulants administration
por: Mori, Misato, et al.
Publicado: (2022)

Phosphorylation Dynamics of JNK Signaling: Effects of Dual-Specificity Phosphatases (DUSPs) on the JNK Pathway
por: Ha, Jain, et al.
Publicado: (2019)

Ceramides bind VDAC2 to trigger mitochondrial apoptosis
por: Dadsena, Shashank, et al.
Publicado: (2019)

Sphingomyelin synthase-related protein generates diacylglycerol via the hydrolysis of glycerophospholipids in the absence of ceramide
por: Murakami, Chiaki, et al.
Publicado: (2021)

Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein
por: Deng, Li-Juan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_um9e3dbsl8lcsr7ahss60b6fme