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Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity

The small Rho GTPase Cdc42, known to interact with Wiskott–Aldrich syndrome (WAS) protein, is an important regulator of actin remodeling. Here, we show that genetic ablation of Cdc42 exclusively in the B cell lineage is sufficient to render mice unable to mount antibody responses. Indeed Cdc42-defic...

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Detalles Bibliográficos
Autores principales: Burbage, Marianne, Keppler, Selina J., Gasparrini, Francesca, Martínez-Martín, Nuria, Gaya, Mauro, Feest, Christoph, Domart, Marie-Charlotte, Brakebusch, Cord, Collinson, Lucy, Bruckbauer, Andreas, Batista, Facundo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291523/
https://www.ncbi.nlm.nih.gov/pubmed/25547673
http://dx.doi.org/10.1084/jem.20141143