Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8(+) T-cell response, prominent infiltration of CD8(+) lymphocytes and Th1 type polarization

Late stage cancer is often associated with reduced immune recognition and a highly immunosuppressive tumor microenvironment. The presence of tumor infiltrating lymphocytes (TILs) and specific gene-signatures prior to treatment are linked to good prognosis, while the opposite is true for extensive im...

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Detalles Bibliográficos
Autores principales: Ranki, Tuuli, Joensuu, Timo, Jäger, Elke, Karbach, Julia, Wahle, Claudia, Kairemo, Kalevi, Alanko, Tuomo, Partanen, Kaarina, Turkki, Riku, Linder, Nina, Lundin, Johan, Ristimäki, Ari, Kankainen, Matti, Hemminki, Akseli, Backman, Charlotta, Dienel, Kasper, von Euler, Mikael, Haavisto, Elina, Hakonen, Tiina, Juhila, Juuso, Jaderberg, Magnus, Priha, Petri, Vassilev, Lotta, Vuolanto, Antti, Pesonen, Sari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292415/
https://www.ncbi.nlm.nih.gov/pubmed/25941579
http://dx.doi.org/10.4161/21624011.2014.958937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292415/
https://www.ncbi.nlm.nih.gov/pubmed/25941579
http://dx.doi.org/10.4161/21624011.2014.958937

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