Lenalidomide induces degradation of IKZF1 and IKZF3

Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to degrade th...

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Detalles Bibliográficos
Autores principales: Krönke, Jan, Hurst, Slater N, Ebert, Benjamin L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292522/
https://www.ncbi.nlm.nih.gov/pubmed/25610725
http://dx.doi.org/10.4161/21624011.2014.941742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292522/
https://www.ncbi.nlm.nih.gov/pubmed/25610725
http://dx.doi.org/10.4161/21624011.2014.941742

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