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Profiling of cis-Diol-containing Nucleosides and Ribosylated Metabolites by Boronate-affinity Organic-silica Hybrid Monolithic Capillary Liquid Chromatography/Mass Spectrometry

RNA contains a large number of modified nucleosides. In the metabolic re-exchange of RNA, modified nucleosides cannot be recycled and are thus excreted from cells into biological fluids. Determination of endogenous modified nucleosides in biological fluids may serve as non-invasive cancers diagnosti...

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Detalles Bibliográficos
Autores principales: Jiang, Han-Peng, Qi, Chu-Bo, Chu, Jie-Mei, Yuan, Bi-Feng, Feng, Yu-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293604/
https://www.ncbi.nlm.nih.gov/pubmed/25585609
http://dx.doi.org/10.1038/srep07785