Small Bowel Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: The First Study in Iran

BACKGROUND Small intestinal bacterial overgrowth (SIBO) may have a role in the pathophysiology of irritable bowel syndrome (IBS). So, the aim of this study was to assess the association between SIBO and IBS by using glucose breath test (GBT) in Kerman city as the first study in Iranian population. M...

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Autores principales: Abbasi, Mehdi HayatBakhsh, Zahedi, MohammadJavad, Darvish Moghadam, Sodaif, Shafieipour, Sara, HayatBakhsh Abbasi, Mahroo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293799/
https://www.ncbi.nlm.nih.gov/pubmed/25628852
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author Abbasi, Mehdi HayatBakhsh
Zahedi, MohammadJavad
Darvish Moghadam, Sodaif
Shafieipour, Sara
HayatBakhsh Abbasi, Mahroo
author_facet Abbasi, Mehdi HayatBakhsh
Zahedi, MohammadJavad
Darvish Moghadam, Sodaif
Shafieipour, Sara
HayatBakhsh Abbasi, Mahroo
author_sort Abbasi, Mehdi HayatBakhsh
collection PubMed
description BACKGROUND Small intestinal bacterial overgrowth (SIBO) may have a role in the pathophysiology of irritable bowel syndrome (IBS). So, the aim of this study was to assess the association between SIBO and IBS by using glucose breath test (GBT) in Kerman city as the first study in Iranian population. METHODS 107 patients with IBS and 107 healthy individuals were enrolled in our study. All the participants underwent GBT. A peak of H2 values >20 p.p.m above the basal value after glucose ingestion was considered suggestive of SIBO. SPSS software version 17 was used for data analysis. P value < 0.05 was considered as statistically significant. RESULTS Of the 107 patients with IBS, 40 had positive GBT (37.4%) compared with 14 (12.1%) out of the 107 control participants(p< 0.001). Dominant symptoms in patients with IBS were diarrhea in 36(33.6%), constipation in 12(11.2%), abdominal pain in 22(20.6%), bloating in 28(26.2%), and change in bowel habit in 9(8.4%) patients. There was not statistically significant difference among any of this IBS subgroups and positive GBT (p=0.44). CONCLUSION There is a positive association between IBS and SIBO. We suggest a Placebo-controlled bacterial eradication study for identifying the role of SIBO in IBS.
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spelling pubmed-42937992015-01-27 Small Bowel Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: The First Study in Iran Abbasi, Mehdi HayatBakhsh Zahedi, MohammadJavad Darvish Moghadam, Sodaif Shafieipour, Sara HayatBakhsh Abbasi, Mahroo Middle East J Dig Dis Original Article BACKGROUND Small intestinal bacterial overgrowth (SIBO) may have a role in the pathophysiology of irritable bowel syndrome (IBS). So, the aim of this study was to assess the association between SIBO and IBS by using glucose breath test (GBT) in Kerman city as the first study in Iranian population. METHODS 107 patients with IBS and 107 healthy individuals were enrolled in our study. All the participants underwent GBT. A peak of H2 values >20 p.p.m above the basal value after glucose ingestion was considered suggestive of SIBO. SPSS software version 17 was used for data analysis. P value < 0.05 was considered as statistically significant. RESULTS Of the 107 patients with IBS, 40 had positive GBT (37.4%) compared with 14 (12.1%) out of the 107 control participants(p< 0.001). Dominant symptoms in patients with IBS were diarrhea in 36(33.6%), constipation in 12(11.2%), abdominal pain in 22(20.6%), bloating in 28(26.2%), and change in bowel habit in 9(8.4%) patients. There was not statistically significant difference among any of this IBS subgroups and positive GBT (p=0.44). CONCLUSION There is a positive association between IBS and SIBO. We suggest a Placebo-controlled bacterial eradication study for identifying the role of SIBO in IBS. Iranian Association of Gastroerterology and Hepatology 2015-01 /pmc/articles/PMC4293799/ /pubmed/25628852 Text en © 2015 by Middle East Journal of Digestive Diseases This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-sa/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Abbasi, Mehdi HayatBakhsh
Zahedi, MohammadJavad
Darvish Moghadam, Sodaif
Shafieipour, Sara
HayatBakhsh Abbasi, Mahroo
Small Bowel Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: The First Study in Iran
title Small Bowel Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: The First Study in Iran
title_full Small Bowel Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: The First Study in Iran
title_fullStr Small Bowel Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: The First Study in Iran
title_full_unstemmed Small Bowel Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: The First Study in Iran
title_short Small Bowel Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: The First Study in Iran
title_sort small bowel bacterial overgrowth in patients with irritable bowel syndrome: the first study in iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293799/
https://www.ncbi.nlm.nih.gov/pubmed/25628852
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