Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition

Here, we used quantitative proteomics analysis to identify novel therapeutic targets in cancer stem cells and/or progenitor cells. For this purpose, mammospheres from two ER-positive breast cancer cell lines (MCF7 and T47D) were grown in suspension using low-attachment plates and directly compared t...

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Detalles Bibliográficos
Autores principales: Lamb, Rebecca, Harrison, Hannah, Hulit, James, Smith, Duncan L., Lisanti, Michael P., Sotgia, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294326/
https://www.ncbi.nlm.nih.gov/pubmed/25415228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294326/
https://www.ncbi.nlm.nih.gov/pubmed/25415228

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