Cargando…

Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition

Docetaxel (DTX) is a useful chemotherapeutic drug for the treatment of hormone-refractory prostate cancer. However, emergence of DTX resistance has been a therapeutic hurdle. In this study, we investigated the effect of combining DTX with Bcl-2 family inhibitors using human prostate cancer cell line...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tamaki, Hiroki, Harashima, Nanae, Hiraki, Miho, Arichi, Naoko, Nishimura, Nobuhiro, Shiina, Hiroaki, Naora, Kohji, Harada, Mamoru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294332/ https://www.ncbi.nlm.nih.gov/pubmed/25333266

Ejemplares similares

Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL
por: Hari, Yoko, et al.
Publicado: (2015)

Versican is a potential therapeutic target in docetaxel-resistant prostate cancer
por: Arichi, Naoko, et al.
Publicado: (2015)

Docetaxel induces Bcl-2- and pro-apoptotic caspase-independent death of human prostate cancer DU145 cells
por: OGURA, TAKEHARU, et al.
Publicado: (2016)

The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells
por: Zhang, Min, et al.
Publicado: (2015)

HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression
por: Harashima, Nanae, et al.
Publicado: (2017)

Choroidal and Cutaneous Metastasis from Urothelial Carcinoma of the Bladder after Radical Cystectomy: A Case Report and Literature Review
por: Mitsui, Yozo, et al.
Publicado: (2014)

Extracellular activation of Wnt signaling through epigenetic dysregulation of Wnt inhibitory factor-1 (Wif-1) is associated with pathogenesis of adrenocortical tumor
por: Mitsui, Yozo, et al.
Publicado: (2014)

Pifithrin-μ, an Inhibitor of Heat-Shock Protein 70, Can Increase the Antitumor Effects of Hyperthermia Against Human Prostate Cancer Cells
por: Sekihara, Kazumasa, et al.
Publicado: (2013)

Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system
por: Harashima, Nanae, et al.
Publicado: (2014)

Molecular Mechanism of Matrine from Sophora alopecuroides in the Reversing Effect of Multi-Anticancer Drug Resistance in K562/ADR Cells
por: Chen, Zhi, et al.
Publicado: (2019)

Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state
por: Tongu, Miki, et al.
Publicado: (2015)

Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer
por: Tanino, Ryosuke, et al.
Publicado: (2018)

Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia
por: Ishihara, Noriyuki, et al.
Publicado: (2020)

Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways
por: Mitsui, Yozo, et al.
Publicado: (2015)

Contrasting effects of cyclophosphamide on anti‐CTL‐associated protein 4 blockade therapy in two mouse tumor models
por: Iida, Yuichi, et al.
Publicado: (2017)

CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma
por: Mitsui, Yozo, et al.
Publicado: (2015)

Correction: CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma
por: Mitsui, Yozo, et al.
Publicado: (2022)

Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2
por: LI, LIN, et al.
Publicado: (2016)

Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2
por: Li, Lin, et al.
Publicado: (2019)

Bcl-2 inhibition sensitizes triple-negative human breast cancer cells to doxorubicin
por: Inao, Touko, et al.
Publicado: (2018)

Inhibition of Caspases Inhibits the Release of Apoptotic Bodies: Bcl-2 Inhibits the Initiation of Formation of Apoptotic Bodies in Chemotherapeutic Agent-induced Apoptosis
por: Zhang, Jiandi, et al.
Publicado: (1999)

Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes
por: Muscari, Isabella, et al.
Publicado: (2020)

An unexpected role for caspase-2 in neuroblastoma
por: Dorstyn, L, et al.
Publicado: (2014)

Identification of Cyclophilin B‐derived Peptides Capable of Inducing Histocompatibility Leukocyte Antigen‐A2‐restricted and Tumor‐specific Cytotoxic T Lymphocytes
por: Tamura, Mayumi, et al.
Publicado: (2001)

Caspase Induction and BCL2 Inhibition in Human Adipose Tissue: A potential relationship with insulin signaling alteration
por: Tinahones, Francisco José, et al.
Publicado: (2013)

Bcl-2 inhibits the caspase-dependent apoptosis induced by SARS-CoV without affecting virus replication kinetics
por: Bordi, L., et al.
Publicado: (2005)

Pulmonary Pharmacokinetic and Pharmacodynamic Evaluation of Ampicillin/Sulbactam Regimens for Pneumonia Caused by Various Bacteria, including Acinetobacter baumannii
por: Onita, Tetsushu, et al.
Publicado: (2023)

Hybrid procedure using perineal and abdominal approaches for radical prostatocystectomy: initial experience with 16 select cases
por: Mitsui, Yozo, et al.
Publicado: (2013)

Discovery of Novel Dimeric Pyridinium Bromide Analogues Inhibits Cancer Cell Growth by Activating Caspases and Downregulating Bcl-2 Protein
por: Govindaraj, Senthilnathan, et al.
Publicado: (2023)

Serine Proteinase Inhibitor 9 Can Be Recognized by Cytotoxic T Lymphocytes of Epithelial Cancer Patients
por: Tanaka, Koji, et al.
Publicado: (2002)

Inflammasome and caspase-1 inhibition caused by Bcl-2 and Bcl-X(L )may influence cytokine responses of lipopolysaccharide-stimulated peripheral blood mononuclear cells from septic patients
por: Liu, Zhao-Jun, et al.
Publicado: (2012)

Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition
por: Arbab, Ismail Adam, et al.
Publicado: (2012)

Follistatin‐like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase‐dependent apoptosis and regulating Bcl‐2 family proteins
por: Li, Chunlei, et al.
Publicado: (2018)

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
por: Yosef, Reut, et al.
Publicado: (2016)

BCL6 inhibition ameliorates resistance to ruxolitinib in CRLF2-rearranged acute lymphoblastic leukemia
por: Tsuzuki, Shinobu, et al.
Publicado: (2022)

Unexpected responses to EGFR inhibition in NSCLC
por: Stella, Giulia M., et al.
Publicado: (2015)

Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase
por: Li, JiaNan, et al.
Publicado: (2019)

Inhibition of calpain but not caspase activity by spectrin fragments
por: Rolius, Ramunas, et al.
Publicado: (2010)

Bcl2 inhibition of mitochondrial DNA repair
por: Xie, Maohua, et al.
Publicado: (2015)

Atorvastatin inhibits cholesterol-induced caspase-3 cleavage through down-regulation of p38 and up-regulation of Bcl-2 in the rat carotid artery
por: Bayatmakoo, Roshanak, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_a4moijtmkhfj9n4o82e3udt0om