Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma

Metformin has been shown to inhibit tumor growth in xenograft rodent models of adult cancers, and various human clinical trials are in progress. However, the precise molecular mechanisms of metformin action are largely unknown. In the present study we examined the anti-tumor activity of metformin ag...

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Detalles Bibliográficos
Autores principales: Kumar, Ambrish, Al-Sammarraie, Nadia, DiPette, Donald J., Singh, Ugra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294363/
https://www.ncbi.nlm.nih.gov/pubmed/25365944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294363/
https://www.ncbi.nlm.nih.gov/pubmed/25365944

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