Transcription Activator-Like Effector Nuclease (TALEN)-Mediated CLYBL Targeting Enables Enhanced Transgene Expression and One-Step Generation of Dual Reporter Human Induced Pluripotent Stem Cell (iPSC) and Neural Stem Cell (NSC) Lines

Targeted genome engineering to robustly express transgenes is an essential methodology for stem cell-based research and therapy. Although designer nucleases have been used to drastically enhance gene editing efficiency, targeted addition and stable expression of transgenes to date is limited at sing...

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Bibliografische gegevens
Hoofdauteurs: Cerbini, Trevor, Funahashi, Ray, Luo, Yongquan, Liu, Chengyu, Park, Kyeyoon, Rao, Mahendra, Malik, Nasir, Zou, Jizhong
Formaat: Online Artikel Texto
Taal:English
Gepubliceerd in: Public Library of Science 2015
Onderwerpen:
Research Article
Online toegang:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294658/
https://www.ncbi.nlm.nih.gov/pubmed/25587899
http://dx.doi.org/10.1371/journal.pone.0116032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294658/
https://www.ncbi.nlm.nih.gov/pubmed/25587899
http://dx.doi.org/10.1371/journal.pone.0116032

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