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The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins
Misfolded proteins of the secretory pathway are extracted from the endoplasmic reticulum (ER), polyubiquitylated by a protein complex termed the Hmg-CoA reductase degradation ligase (HRD-ligase), and degraded by cytosolic 26S proteasomes. This process is termed ER-associated protein degradation (ERA...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294667/ https://www.ncbi.nlm.nih.gov/pubmed/25428985 http://dx.doi.org/10.1091/mbc.E14-07-1202 |