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The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins

Misfolded proteins of the secretory pathway are extracted from the endoplasmic reticulum (ER), polyubiquitylated by a protein complex termed the Hmg-CoA reductase degradation ligase (HRD-ligase), and degraded by cytosolic 26S proteasomes. This process is termed ER-associated protein degradation (ERA...

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Detalles Bibliográficos
Autores principales:	Mehnert, Martin, Sommermeyer, Franziska, Berger, Maren, Kumar Lakshmipathy, Sathish, Gauss, Robert, Aebi, Markus, Jarosch, Ernst, Sommer, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294667/ https://www.ncbi.nlm.nih.gov/pubmed/25428985 http://dx.doi.org/10.1091/mbc.E14-07-1202

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