Cargando…

Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space

The mitochondrial intermembrane space (IMS) harbors an oxidizing machinery that drives import and folding of small cysteine-containing proteins without targeting signals. The main component of this pathway is the oxidoreductase Mia40, which introduces disulfides into its substrates. We recently show...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kojer, Kerstin, Peleh, Valentina, Calabrese, Gaetano, Herrmann, Johannes M., Riemer, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294668/ https://www.ncbi.nlm.nih.gov/pubmed/25392302 http://dx.doi.org/10.1091/mbc.E14-10-1422

Ejemplares similares

Protein oxidation in the intermembrane space of mitochondria is substrate-specific rather than general
por: Peleh, Valentina, et al.
Publicado: (2014)

Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells
por: Fischer, Manuel, et al.
Publicado: (2013)

Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding
por: Peleh, Valentina, et al.
Publicado: (2016)

Erv1 of Arabidopsis thaliana can directly oxidize mitochondrial intermembrane space proteins in the absence of redox-active Mia40
por: Peleh, Valentina, et al.
Publicado: (2017)

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes
por: Ebersoll, Samantha, et al.
Publicado: (2018)

Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding
por: Kritsiligkou, Paraskevi, et al.
Publicado: (2017)

A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space
por: Mattie, Sevan, et al.
Publicado: (2018)

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins
por: Kowalski, Lukasz, et al.
Publicado: (2018)

Intermembrane Space Proteome of Yeast Mitochondria
por: Vögtle, F.-Nora, et al.
Publicado: (2012)

Protein Translocation into the Intermembrane Space and Matrix of Mitochondria: Mechanisms and Driving Forces
por: Backes, Sandra, et al.
Publicado: (2017)

Oxidative Folding in the Mitochondrial Intermembrane Space in Human Health and Disease
por: Fraga, Hugo, et al.
Publicado: (2013)

Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space
por: Manganas, Phanee, et al.
Publicado: (2016)

Myristoyl group-aided protein import into the mitochondrial intermembrane space
por: Ueda, Eri, et al.
Publicado: (2019)

An intermembrane space protein facilitates completion of mitochondrial division in yeast
por: Connor, Olivia M., et al.
Publicado: (2023)

Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2
por: Liu, Peipei, et al.
Publicado: (2017)

Catch me if you can! Oxidative protein trapping in the intermembrane space of mitochondria
por: Herrmann, Johannes M., et al.
Publicado: (2007)

Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches
por: López-Grueso, MJ, et al.
Publicado: (2018)

To Mia or not to Mia: stepwise evolution of the mitochondrial intermembrane space disulfide relay
por: Carrie, Chris, et al.
Publicado: (2017)

Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space
por: Weinhäupl, Katharina, et al.
Publicado: (2018)

Protein trafficking in the mitochondrial intermembrane space: mechanisms and links to human disease
por: MacPherson, Lisa, et al.
Publicado: (2017)

Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging
por: Vega, Montserrat, et al.
Publicado: (2022)

The mitochondrial intermembrane space–facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism
por: Odendall, Fenja, et al.
Publicado: (2019)

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space
por: Adriaenssens, Elias, et al.
Publicado: (2023)

MEMBRANE JUNCTIONS IN THE INTERMEMBRANE SPACE OF MITOCHONDRIA FROM MAMMALIAN TISSUES
por: Saito, Akitsugu, et al.
Publicado: (1974)

DNA nanostructure‐programmed intermembrane spacing to modulate T‐cell immunity
por: Du, Yulin, et al.
Publicado: (2023)

The mitochondrial intermembrane space: the most constricted mitochondrial sub-compartment with the largest variety of protein import pathways
por: Edwards, Ruairidh, et al.
Publicado: (2021)

The glutaredoxin mono- and di-thiol mechanisms for deglutathionylation are functionally equivalent: implications for redox systems biology
por: Mashamaite, Lefentse N., et al.
Publicado: (2015)

Glutaredoxins employ parallel monothiol–dithiol mechanisms to catalyze thiol–disulfide exchanges with protein disulfides
por: Ukuwela, Ashwinie A., et al.
Publicado: (2017)

Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space
por: Cardenas‐Rodriguez, Mauricio, et al.
Publicado: (2017)

Oxidative folding in the mitochondrial intermembrane space: A regulated process important for cell physiology and disease
por: Chatzi, Afroditi, et al.
Publicado: (2016)

CUP1 Metallothionein from Healthy Saccharomyces cerevisiae Colocalizes to the Cytosol and Mitochondrial Intermembrane Space
por: Kim, Joshua E., et al.
Publicado: (2022)

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria
por: Schreiner, Bernadette, et al.
Publicado: (2012)

Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk
por: Nuebel, Esther, et al.
Publicado: (2016)

The Mia40/CHCHD4 Oxidative Folding System: Redox Regulation and Signaling in the Mitochondrial Intermembrane Space
por: Dickson-Murray, Eleanor, et al.
Publicado: (2021)

A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria
por: Gornicka, Agnieszka, et al.
Publicado: (2014)

Uncoupling protein 3 attenuates generation of reactive oxygen species by interacting with thioredoxin 2 in the mitochondrial intermembrane space
por: Hirasaka, Katsuya, et al.
Publicado: (2012)

Correction for Precursor Oxidation by Mia40 and Erv1 Promotes Vectorial Transport of Proteins into the Mitochondrial Intermembrane Space
Publicado: (2014)

A novel intermembrane space–targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding
por: Sideris, Dionisia P., et al.
Publicado: (2009)

Armadillo repeat-containing protein 1 is a dual localization protein associated with mitochondrial intermembrane space bridging complex
por: Wagner, Fabienne, et al.
Publicado: (2019)

Analyzing structural alterations of mitochondrial intermembrane space superoxide scavengers cytochrome-c and SOD1 after methylglyoxal treatment
por: Mercado-Uribe, Hilda, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ogcla6j1qucu1bddsd4mq1u6a0