Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease. However, the location(s) of proteolytic processing and subsequent secretion of APP fragments from highly compartmentalized, euploid neurons...

Descripción completa

Detalles Bibliográficos
Autores principales: Niederst, Emily D., Reyna, Sol M., Goldstein, Lawrence S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294669/
https://www.ncbi.nlm.nih.gov/pubmed/25392299
http://dx.doi.org/10.1091/mbc.E14-06-1049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294669/
https://www.ncbi.nlm.nih.gov/pubmed/25392299
http://dx.doi.org/10.1091/mbc.E14-06-1049

Ejemplares similares