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Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease. However, the location(s) of proteolytic processing and subsequent secretion of APP fragments from highly compartmentalized, euploid neurons...

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Detalles Bibliográficos
Autores principales:	Niederst, Emily D., Reyna, Sol M., Goldstein, Lawrence S. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294669/ https://www.ncbi.nlm.nih.gov/pubmed/25392299 http://dx.doi.org/10.1091/mbc.E14-06-1049

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