Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes

Bax induces mitochondrial outer membrane permeabilization (MOMP), a critical step in apoptosis in which proteins are released into the cytoplasm. To resolve aspects of the mechanism, we used cryo-electron microscopy (cryo-EM) to visualize Bax-induced pores in purified mitochondrial outer membranes (...

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Detalles Bibliográficos
Autores principales: Gillies, Laura A, Du, Han, Peters, Bjoern, Knudson, C. Michael, Newmeyer, Donald D., Kuwana, Tomomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294680/
https://www.ncbi.nlm.nih.gov/pubmed/25411335
http://dx.doi.org/10.1091/mbc.E13-11-0638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294680/
https://www.ncbi.nlm.nih.gov/pubmed/25411335
http://dx.doi.org/10.1091/mbc.E13-11-0638

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