Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca(2+) signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, is unclear. Here, we report that lysosomes are enlarged and aggregated in fibroblasts from Parkinson disease patients...

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Detalles Bibliográficos
Autores principales: Hockey, Leanne N., Kilpatrick, Bethan S., Eden, Emily R., Lin-Moshier, Yaping, Brailoiu, G. Cristina, Brailoiu, Eugen, Futter, Clare E., Schapira, Anthony H., Marchant, Jonathan S., Patel, Sandip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294771/
https://www.ncbi.nlm.nih.gov/pubmed/25416817
http://dx.doi.org/10.1242/jcs.164152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294771/
https://www.ncbi.nlm.nih.gov/pubmed/25416817
http://dx.doi.org/10.1242/jcs.164152

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