Cargando…
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition
Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca(2+) signalling from acidic organelles. The relevance of these ubiquitous proteins for human disease, however, is unclear. Here, we report that lysosomes are enlarged and aggregated in fibroblasts from Parkinson disease patients...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294771/ https://www.ncbi.nlm.nih.gov/pubmed/25416817 http://dx.doi.org/10.1242/jcs.164152 |