Ash2L enables P53–dependent apoptosis by favoring stable transcription pre–initiation complex formation on its pro-apoptotic target promoters

Chromatin conformation plays a major role in all cellular decisions. We showed previously that P53 pro-apoptotic target promoters are enriched with H3K9me3 mark and induction of P53 abrogates this repressive chromatin conformation by down-regulating SUV39H1, the writer of this mark present on these...

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Detalles Bibliográficos
Autores principales: Mungamuri, Sathish Kumar, Wang, Shaomeng, Manfredi, James J., Gu, Wei, Aaronson, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295002/
https://www.ncbi.nlm.nih.gov/pubmed/25023704
http://dx.doi.org/10.1038/onc.2014.198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295002/
https://www.ncbi.nlm.nih.gov/pubmed/25023704
http://dx.doi.org/10.1038/onc.2014.198

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