Cargando…
Phase 1 trial of tivantinib in combination with sorafenib in adult patients with advanced solid tumors
Purpose This phase I study evaluated the safety, tolerability, maximum tolerated dose (MTD), and recommended phase II dose (RP2D) of tivantinib combined with sorafenib in patients with advanced solid tumors. Materials and Methods A standard 3 + 3 dose escalation design was used. At the RP2D, expansi...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295023/ https://www.ncbi.nlm.nih.gov/pubmed/25294187 http://dx.doi.org/10.1007/s10637-014-0167-5 |