Development of a High Affinity, Non-covalent Biologic to Add Functionality to Fabs

Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with protein heterogeneity, stability and solubility. Such perturbations could potentially be avoided by using a high affinity, non-covalent interm...

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Detalles Bibliográficos
Autores principales: Avery, Kendra N., Zer, Cindy, Bzymek, Krzysztof P., Williams, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295097/
https://www.ncbi.nlm.nih.gov/pubmed/25588710
http://dx.doi.org/10.1038/srep07817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295097/
https://www.ncbi.nlm.nih.gov/pubmed/25588710
http://dx.doi.org/10.1038/srep07817

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