Comparison of anticipated and actual control group outcomes in randomised trials in paediatric oncology provides evidence that historically controlled studies are biased in favour of the novel treatment

BACKGROUND: Historically controlled studies are commonly undertaken in paediatric oncology, despite their potential biases. Our aim was to compare the outcome of the control group in randomised controlled trials (RCTs) in paediatric oncology with those anticipated in the sample size calculations in...

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Detalles Bibliográficos
Autores principales: Moroz, Veronica, Wilson, Jayne S, Kearns, Pamela, Wheatley, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295234/
https://www.ncbi.nlm.nih.gov/pubmed/25490968
http://dx.doi.org/10.1186/1745-6215-15-481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295234/
https://www.ncbi.nlm.nih.gov/pubmed/25490968
http://dx.doi.org/10.1186/1745-6215-15-481

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