Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

High-fat diet (HFD) and inflammation are the key contributors to insulin resistance and type 2 diabetes (T2D). Previous study shows fatty acid-induced accumulation of damaged, reactive oxygen species (ROS)-generating mitochondria, and this in turn activates the NLRP3 inflammasome interference with i...

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Detalles Bibliográficos
Autores principales: Yang, Sijun, Xia, Chunxiang, Li, Shali, Du, Leilei, Zhang, Lu, Zhou, Ronbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295565/
https://www.ncbi.nlm.nih.gov/pubmed/25462067
http://dx.doi.org/10.1016/j.redox.2014.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295565/
https://www.ncbi.nlm.nih.gov/pubmed/25462067
http://dx.doi.org/10.1016/j.redox.2014.04.001

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