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Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity
High-fat diet (HFD) and inflammation are the key contributors to insulin resistance and type 2 diabetes (T2D). Previous study shows fatty acid-induced accumulation of damaged, reactive oxygen species (ROS)-generating mitochondria, and this in turn activates the NLRP3 inflammasome interference with i...
Autores principales: | Yang, Sijun, Xia, Chunxiang, Li, Shali, Du, Leilei, Zhang, Lu, Zhou, Ronbin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295565/ https://www.ncbi.nlm.nih.gov/pubmed/25462067 http://dx.doi.org/10.1016/j.redox.2014.04.001 |
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