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Ranolazine inhibits Na(V)1.5-mediated breast cancer cell invasiveness and lung colonization
BACKGROUND: Na(V)1.5 voltage-gated sodium channels are abnormally expressed in breast tumours and their expression level is associated with metastatic occurrence and patients’ death. In breast cancer cells, Na(V)1.5 activity promotes the proteolytic degradation of the extracellular matrix and enhanc...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295566/ https://www.ncbi.nlm.nih.gov/pubmed/25496128 http://dx.doi.org/10.1186/1476-4598-13-264 |