Quantitative PCR Analysis of DNA Aptamer Pharmacokinetics in Mice

DNA aptamer oligonucleotides and their protein conjugates show promise as therapeutics in animal models of diseases such as multiple sclerosis. These molecules are large and highly charged, raising questions about their biodistribution and pharmacokinetics in mammals. Here we exploit the power of qu...

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Detalles Bibliográficos
Autores principales: Perschbacher, Katherine, Smestad, John A., Peters, Justin P., Standiford, Miranda M., Denic, Aleksandar, Wootla, Bharath, Warrington, Arthur E., Rodriguez, Moses, Maher, L. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296750/
https://www.ncbi.nlm.nih.gov/pubmed/25536292
http://dx.doi.org/10.1089/nat.2014.0515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296750/
https://www.ncbi.nlm.nih.gov/pubmed/25536292
http://dx.doi.org/10.1089/nat.2014.0515

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