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Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABA(A) receptor ligands
We present the synthesis of new derivatives of natural products magnolol (1) and honokiol (2) and their evaluation as allosteric ligands for modulation of GABA(A) receptor activity. New derivatives were prepared via metal assisted cross-coupling reactions in two consecutive steps. Compounds were tes...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297288/ https://www.ncbi.nlm.nih.gov/pubmed/25510374 http://dx.doi.org/10.1016/j.bmcl.2014.10.091 |