Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

BACKGROUND: The β-secretase, BACE1, cleaves APP to initiate generation of the β-amyloid peptide, Aβ, that comprises amyloid plaques in Alzheimer’s disease (AD). Reducing BACE1 activity is an attractive therapeutic approach to AD, but complete inhibition of BACE1 could have mechanism-based side-effec...

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Detalles Bibliográficos
Autores principales: Sadleir, Katherine R, Eimer, William A, Cole, Sarah L, Vassar, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297413/
https://www.ncbi.nlm.nih.gov/pubmed/25567526
http://dx.doi.org/10.1186/1750-1326-10-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297413/
https://www.ncbi.nlm.nih.gov/pubmed/25567526
http://dx.doi.org/10.1186/1750-1326-10-1

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