The phosphatase PTEN-mediated control of PI-3 kinase in T(regs) cells maintains homeostasis and lineage stability

Foxp3(+) regulatory T cells (T(regs)) are required for immune homeostasis. One notable distinction between conventional T cells (T(conv)) and T(regs) is differential phosphatidylinositol 3-kinase (PI3K) activity: only T(conv) downregulate PTEN, the primary negative regulator of PI3K, upon activation...

Descripción completa

Detalles Bibliográficos
Autores principales: Huynh, Alexandria, DuPage, Michel, Priyadharshini, Bhavana, Sage, Peter T., Quiros, Jason, Borges, Christopher M., Townamchai, Natavudh, Gerriets, Valerie A., Rathmell, Jeffrey C., Sharpe, Arlene H., Bluestone, Jeffrey A., Turka, Laurence A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297515/
https://www.ncbi.nlm.nih.gov/pubmed/25559257
http://dx.doi.org/10.1038/ni.3077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297515/
https://www.ncbi.nlm.nih.gov/pubmed/25559257
http://dx.doi.org/10.1038/ni.3077

Ejemplares similares