Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

Efavirenz (EFV) is an anti-retroviral drug frequently combined with isoniazid (INH) to treat HIV-1/tuberculosis co-infected patients. Both drugs have been associated with idiosyncratic liver injury (DILI), but combined anti-retroviral and anti-tubercular therapy can increase the risk for DILI as com...

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Detalles Bibliográficos
Autores principales: Lee, Kang Kwang, Boelsterli, Urs A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297936/
https://www.ncbi.nlm.nih.gov/pubmed/25460728
http://dx.doi.org/10.1016/j.redox.2014.03.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297936/
https://www.ncbi.nlm.nih.gov/pubmed/25460728
http://dx.doi.org/10.1016/j.redox.2014.03.003

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