Cargando…

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis

INTRODUCTION: The objective of this study was to investigate the possible role of UDP-glucose dehydrogenase (UGDH) in osteoarthritis (OA) and uncover whether, furthermore how interleukin-1beta (IL-1β) affects UGDH gene expression. METHODS: UGDH specific siRNAs were applied to determine the role of U...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Yinxian, Li, Jing, Wang, Linlong, Tie, Kai, Magdalou, Jacques, Chen, Liaobin, Wang, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298080/ https://www.ncbi.nlm.nih.gov/pubmed/25465897 http://dx.doi.org/10.1186/s13075-014-0484-2

Ejemplares similares

Angelica Sinensis Polysaccharides Stimulated UDP-Sugar Synthase Genes through Promoting Gene Expression of IGF-1 and IGF1R in Chondrocytes: Promoting Anti-Osteoarthritic Activity
por: Wen, Yinxian, et al.
Publicado: (2014)

Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis
por: Li, Qingxian, et al.
Publicado: (2021)

Author Correction: Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis
por: Li, Qingxian, et al.
Publicado: (2022)

Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro: A Possible Mechanism to Promote Proteoglycans Synthesis
por: Qin, Jun, et al.
Publicado: (2013)

H3K9ac of TGFβRI in human umbilical cord: a potential biomarker for evaluating cartilage differentiation and susceptibility to osteoarthritis via a two-step strategy
por: Qi, Yongjian, et al.
Publicado: (2021)

Cloning, Expression and Characterization of UDP-Glucose Dehydrogenases
por: Couto, Márcia R., et al.
Publicado: (2021)

Chondrocyte number and proteoglycan synthesis in the ageing and osteoarthritic human articular cartilage
por: Bobacz, K, et al.
Publicado: (2003)

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase
por: Egger, Sigrid, et al.
Publicado: (2011)

Structural Basis of Cooperativity in Human UDP-Glucose Dehydrogenase
por: Rajakannan, Venkatachalam, et al.
Publicado: (2011)

Prenatal caffeine exposure induces a poor quality of articular cartilage in male adult offspring rats via cholesterol accumulation in cartilage
por: Luo, Hanwen, et al.
Publicado: (2015)

Conservation of Atypical Allostery in C. elegans UDP-Glucose Dehydrogenase
por: Beattie, Nathaniel R., et al.
Publicado: (2019)

UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology
por: Price, Meghan J., et al.
Publicado: (2023)

Targeting UDP‐glucose dehydrogenase inhibits ovarian cancer growth and metastasis
por: Lin, Li‐Hsun, et al.
Publicado: (2020)

Intra-articular versus systemic vancomycin for the treatment of periprosthetic joint infection after debridement and spacer implantation in a rat model
por: Wei, Jian, et al.
Publicado: (2022)

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication
por: Ouzzine, Mohamed, et al.
Publicado: (2014)

Prenatal ethanol exposure increases osteoarthritis susceptibility in female rat offspring by programming a low-functioning IGF-1 signaling pathway
por: Ni, Qubo, et al.
Publicado: (2015)

UDP-α-D-glucose 6-dehydrogenase: a promising target for glioblastoma
por: Goodwin, C. Rory, et al.
Publicado: (2019)

Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration
por: Oyinlade, Olutobi, et al.
Publicado: (2018)

Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
por: Chen, Haitao, et al.
Publicado: (2023)

Articular chondrocyte alignment in the rat after surgically induced osteoarthritis
por: Takahashi, Hideaki, et al.
Publicado: (2017)

Arabidopsis MAP-Kinase 3 Phosphorylates UDP-Glucose Dehydrogenase: a Key Enzyme Providing UDP-Sugar for Cell Wall Biosynthesis
por: Kohlberger, Michael, et al.
Publicado: (2018)

Chondrocyte death involvement in osteoarthritis
por: Salucci, S., et al.
Publicado: (2022)

Cloning and endogenous expression of a Eucalyptus grandis UDP-glucose dehydrogenase cDNA
por: Labate, Mônica T. Veneziano, et al.
Publicado: (2010)

UDP-Glucose Dehydrogenases: Identification, Expression, and Function Analyses in Upland Cotton (Gossypium hirsutum)
por: Jia, Tingting, et al.
Publicado: (2021)

Cyclooxygenase-2 regulates PTHrP transcription in human articular chondrocytes and is involved in the pathophysiology of osteoarthritis in rats
por: Chang, Ling-hua, et al.
Publicado: (2021)

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates
por: Egger, Sigrid, et al.
Publicado: (2012)

Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis
por: Young, Allan A, et al.
Publicado: (2005)

Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)
por: Yudoh, Kazuo, et al.
Publicado: (2010)

Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy
por: Hengel, Holger, et al.
Publicado: (2020)

UDP-Glucose 6-Dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression
por: Arnold, James M., et al.
Publicado: (2019)

Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis
por: Huang, Zhongming, et al.
Publicado: (2016)

Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E(2 )from human articular chondrocytes
por: Masuko, Kayo, et al.
Publicado: (2007)

Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed and stimulate proteoglycan synthesis in healthy and osteoarthritic human articular chondrocytes
por: Bobacz, K, et al.
Publicado: (2001)

The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis
por: Hudetz, Damir, et al.
Publicado: (2017)

Catalytic mechanism of human UDP-glucose 6-dehydrogenase: in situ proton NMR studies reveal that the C-5 hydrogen of UDP-glucose is not exchanged with bulk water during the enzymatic reaction
por: Eixelsberger, Thomas, et al.
Publicado: (2012)

A whole-genome transcriptome analysis of articular chondrocytes in secondary osteoarthritis of the hip
por: Aki, Takashi, et al.
Publicado: (2018)

Tyrosine Phosphorylation of the UDP-Glucose Dehydrogenase of Escherichia coli Is at the Crossroads of Colanic Acid Synthesis and Polymyxin Resistance
por: Lacour, Soline, et al.
Publicado: (2008)

Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase
por: Clarkin, C.E., et al.
Publicado: (2011)

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes
por: Yammani, Raghunatha R, et al.
Publicado: (2012)

Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice
por: Liao, Lifan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_k4bou0kns6g07607ebsdkme1gt