Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

INTRODUCTION: Heavy menstrual bleeding (HMB) diminishes individual quality-of-life and poses substantial societal burden. In HMB endometrium, inactivation of cortisol (by enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2)), may cause local endometrial glucocorticoid deficiency and hence increa...

Descripción completa

Detalles Bibliográficos
Autores principales: Warner, P, Weir, C J, Hansen, C H, Douglas, A, Madhra, M, Hillier, S G, Saunders, P T K, Iredale, J P, Semple, S, Walker, B R, Critchley, H O D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Obstetrics and Gynaecology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298087/
https://www.ncbi.nlm.nih.gov/pubmed/25588784
http://dx.doi.org/10.1136/bmjopen-2014-006837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298087/
https://www.ncbi.nlm.nih.gov/pubmed/25588784
http://dx.doi.org/10.1136/bmjopen-2014-006837

Ejemplares similares