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Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

INTRODUCTION: Heavy menstrual bleeding (HMB) diminishes individual quality-of-life and poses substantial societal burden. In HMB endometrium, inactivation of cortisol (by enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2)), may cause local endometrial glucocorticoid deficiency and hence increa...

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Detalles Bibliográficos
Autores principales:	Warner, P, Weir, C J, Hansen, C H, Douglas, A, Madhra, M, Hillier, S G, Saunders, P T K, Iredale, J P, Semple, S, Walker, B R, Critchley, H O D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2015
Materias:	Obstetrics and Gynaecology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298087/ https://www.ncbi.nlm.nih.gov/pubmed/25588784 http://dx.doi.org/10.1136/bmjopen-2014-006837

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