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Site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study

BACKGROUND: Vascular disease expression in one location may not be representative for disease severity in other vascular territories, however, strong correlation between disease expression and severity within the same vascular segment may be expected. Therefore, we hypothesized that aortic stiffenin...

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Autores principales: van den Bosch, Harrie C M, Westenberg, Jos J M, Setz-Pels, Wikke, Wondergem, John, Wolterbeek, Ron, Duijm, Lucien E M, Teijink, Joep A W, de Roos, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298121/
https://www.ncbi.nlm.nih.gov/pubmed/25600313
http://dx.doi.org/10.1186/s12968-014-0095-8
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author van den Bosch, Harrie C M
Westenberg, Jos J M
Setz-Pels, Wikke
Wondergem, John
Wolterbeek, Ron
Duijm, Lucien E M
Teijink, Joep A W
de Roos, Albert
author_facet van den Bosch, Harrie C M
Westenberg, Jos J M
Setz-Pels, Wikke
Wondergem, John
Wolterbeek, Ron
Duijm, Lucien E M
Teijink, Joep A W
de Roos, Albert
author_sort van den Bosch, Harrie C M
collection PubMed
description BACKGROUND: Vascular disease expression in one location may not be representative for disease severity in other vascular territories, however, strong correlation between disease expression and severity within the same vascular segment may be expected. Therefore, we hypothesized that aortic stiffening is more strongly associated with disease expression in a vascular territory directly linked to that aortic segment rather than in a more remote segment. We prospectively compared the association between aortic wall stiffness, expressed by pulse wave velocity (PWV), sampled in the distal aorta, with the severity of peripheral arterial occlusive disease (PAOD) as compared to atherosclerotic markers sampled in remote vascular territories such as PWV in the proximal aorta and the normalized wall index (NWI), representing the vessel wall thickness, of the left common carotid artery. METHODS: Forty-two patients (23 men; mean age 64±10 years) underwent velocity-encoded cardiovascular magnetic resonance (CMR) in the proximal and distal aorta, whole-body contrast-enhanced MR angiography (CE-MRA) and carotid vessel wall imaging with black-blood CMR in the work-up for PAOD. Strength of associations between aortic stiffness, carotid NWI and peripheral vascular stenosis grade were assessed and evaluated with multiple linear regression. RESULTS: Stenosis severity correlated well with PWV in the distal aorta (Pearson r(P)=0.64, p<0.001, Spearman r(S)=0.65, p<0.001) but to a lesser extent with PWV in the proximal aorta (r(P)=0.48, p=0.002, r(S)=0.22, p=0.18). Carotid NWI was not associated with peripheral stenosis severity (r(P)=0.17, p=0.28, r(S)=0.14, p=0.37) nor with PWV in the proximal aorta (r(P)=0.22, p=0.17) nor in the distal aorta (r(P)=0.21, p=0.18). Correlation between stenosis severity and distal aortic PWV remained statistically significant after correction for age and gender. CONCLUSIONS: Distal aortic wall stiffness is more directly related to peripheral arterial stenosis severity than markers from more remote vascular territories such as proximal aortic wall stiffness or carotid arterial wall thickness. Site-specific evaluation of vascular disease may be required for full vascular risk estimation.
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spelling pubmed-42981212015-01-20 Site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study van den Bosch, Harrie C M Westenberg, Jos J M Setz-Pels, Wikke Wondergem, John Wolterbeek, Ron Duijm, Lucien E M Teijink, Joep A W de Roos, Albert J Cardiovasc Magn Reson Research BACKGROUND: Vascular disease expression in one location may not be representative for disease severity in other vascular territories, however, strong correlation between disease expression and severity within the same vascular segment may be expected. Therefore, we hypothesized that aortic stiffening is more strongly associated with disease expression in a vascular territory directly linked to that aortic segment rather than in a more remote segment. We prospectively compared the association between aortic wall stiffness, expressed by pulse wave velocity (PWV), sampled in the distal aorta, with the severity of peripheral arterial occlusive disease (PAOD) as compared to atherosclerotic markers sampled in remote vascular territories such as PWV in the proximal aorta and the normalized wall index (NWI), representing the vessel wall thickness, of the left common carotid artery. METHODS: Forty-two patients (23 men; mean age 64±10 years) underwent velocity-encoded cardiovascular magnetic resonance (CMR) in the proximal and distal aorta, whole-body contrast-enhanced MR angiography (CE-MRA) and carotid vessel wall imaging with black-blood CMR in the work-up for PAOD. Strength of associations between aortic stiffness, carotid NWI and peripheral vascular stenosis grade were assessed and evaluated with multiple linear regression. RESULTS: Stenosis severity correlated well with PWV in the distal aorta (Pearson r(P)=0.64, p<0.001, Spearman r(S)=0.65, p<0.001) but to a lesser extent with PWV in the proximal aorta (r(P)=0.48, p=0.002, r(S)=0.22, p=0.18). Carotid NWI was not associated with peripheral stenosis severity (r(P)=0.17, p=0.28, r(S)=0.14, p=0.37) nor with PWV in the proximal aorta (r(P)=0.22, p=0.17) nor in the distal aorta (r(P)=0.21, p=0.18). Correlation between stenosis severity and distal aortic PWV remained statistically significant after correction for age and gender. CONCLUSIONS: Distal aortic wall stiffness is more directly related to peripheral arterial stenosis severity than markers from more remote vascular territories such as proximal aortic wall stiffness or carotid arterial wall thickness. Site-specific evaluation of vascular disease may be required for full vascular risk estimation. BioMed Central 2015-01-20 /pmc/articles/PMC4298121/ /pubmed/25600313 http://dx.doi.org/10.1186/s12968-014-0095-8 Text en © van den Bosch et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
van den Bosch, Harrie C M
Westenberg, Jos J M
Setz-Pels, Wikke
Wondergem, John
Wolterbeek, Ron
Duijm, Lucien E M
Teijink, Joep A W
de Roos, Albert
Site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study
title Site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study
title_full Site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study
title_fullStr Site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study
title_full_unstemmed Site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study
title_short Site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study
title_sort site-specific association between distal aortic pulse wave velocity and peripheral arterial stenosis severity: a prospective cardiovascular magnetic resonance study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298121/
https://www.ncbi.nlm.nih.gov/pubmed/25600313
http://dx.doi.org/10.1186/s12968-014-0095-8
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