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Epistasis Constrains Mutational Pathways of Hemoglobin Adaptation in High-Altitude Pikas
A fundamental question in evolutionary genetics concerns the roles of mutational pleiotropy and epistasis in shaping trajectories of protein evolution. This question can be addressed most directly by using site-directed mutagenesis to explore the mutational landscape of protein function in experimen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298171/ https://www.ncbi.nlm.nih.gov/pubmed/25415962 http://dx.doi.org/10.1093/molbev/msu311 |