Epistasis Constrains Mutational Pathways of Hemoglobin Adaptation in High-Altitude Pikas

A fundamental question in evolutionary genetics concerns the roles of mutational pleiotropy and epistasis in shaping trajectories of protein evolution. This question can be addressed most directly by using site-directed mutagenesis to explore the mutational landscape of protein function in experimen...

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Detalles Bibliográficos
Autores principales: Tufts, Danielle M., Natarajan, Chandrasekhar, Revsbech, Inge G., Projecto-Garcia, Joana, Hoffmann, Federico G., Weber, Roy E., Fago, Angela, Moriyama, Hideaki, Storz, Jay F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298171/
https://www.ncbi.nlm.nih.gov/pubmed/25415962
http://dx.doi.org/10.1093/molbev/msu311

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