Multi-input CRISPR/Cas genetic circuits that interface host regulatory networks

Genetic circuits require many regulatory parts in order to implement signal processing or execute algorithms in cells. A potentially scalable approach is to use dCas9, which employs small guide RNAs (sgRNAs) to repress genetic loci via the programmability of RNA:DNA base pairing. To this end, we use...

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Detalles Bibliográficos
Autores principales: Nielsen, Alec AK, Voigt, Christopher A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299604/
https://www.ncbi.nlm.nih.gov/pubmed/25422271
http://dx.doi.org/10.15252/msb.20145735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299604/
https://www.ncbi.nlm.nih.gov/pubmed/25422271
http://dx.doi.org/10.15252/msb.20145735

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