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The role of the interactome in the maintenance of deleterious variability in human populations

Recent genomic projects have revealed the existence of an unexpectedly large amount of deleterious variability in the human genome. Several hypotheses have been proposed to explain such an apparently high mutational load. However, the mechanisms by which deleterious mutations in some genes cause a p...

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Detalles Bibliográficos
Autores principales: Garcia-Alonso, Luz, Jiménez-Almazán, Jorge, Carbonell-Caballero, Jose, Vela-Boza, Alicia, Santoyo-López, Javier, Antiñolo, Guillermo, Dopazo, Joaquin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299661/
https://www.ncbi.nlm.nih.gov/pubmed/25261458
http://dx.doi.org/10.15252/msb.20145222