17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro

BACKGROUND: 17β-estradiol can suppress acute lung injury (ALI) and regulate alveolar epithelial sodium channel (ENaC). However the relationship between these two functions remains unclear. This study is conducted to assess the role of ENaC and the PI3K/Akt/SGK1 signaling pathway in 17β-estradiol the...

Descripción completa

Detalles Bibliográficos
Autores principales: Qi, Di, He, Jing, Wang, Daoxin, Deng, Wang, Zhao, Yan, Ye, Yuan, Feng, Longhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299800/
https://www.ncbi.nlm.nih.gov/pubmed/25551628
http://dx.doi.org/10.1186/s12931-014-0159-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299800/
https://www.ncbi.nlm.nih.gov/pubmed/25551628
http://dx.doi.org/10.1186/s12931-014-0159-1

Ejemplares similares