Structure-Guided Design of Selective Epac1 and Epac2 Agonists

The second messenger cAMP is known to augment glucose-induced insulin secretion. However, its downstream targets in pancreatic β-cells have not been unequivocally determined. Therefore, we designed cAMP analogues by a structure-guided approach that act as Epac2-selective agonists both in vitro and i...

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Detalles Bibliográficos
Autores principales: Schwede, Frank, Bertinetti, Daniela, Langerijs, Carianne N., Hadders, Michael A., Wienk, Hans, Ellenbroek, Johanne H., de Koning, Eelco J. P., Bos, Johannes L., Herberg, Friedrich W., Genieser, Hans-Gottfried, Janssen, Richard A. J., Rehmann, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300089/
https://www.ncbi.nlm.nih.gov/pubmed/25603503
http://dx.doi.org/10.1371/journal.pbio.1002038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300089/
https://www.ncbi.nlm.nih.gov/pubmed/25603503
http://dx.doi.org/10.1371/journal.pbio.1002038

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