Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency

OBJECTIVE: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and me...

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Detalles Bibliográficos
Autores principales: Malhotra, Rajeev, Burke, Megan F., Martyn, Trejeeve, Shakartzi, Hannah R., Thayer, Timothy E., O’Rourke, Caitlin, Li, Pingcheng, Derwall, Matthias, Spagnolli, Ester, Kolodziej, Starsha A., Hoeft, Konrad, Mayeur, Claire, Jiramongkolchai, Pawina, Kumar, Ravindra, Buys, Emmanuel S., Yu, Paul B., Bloch, Kenneth D., Bloch, Donald B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300181/
https://www.ncbi.nlm.nih.gov/pubmed/25603410
http://dx.doi.org/10.1371/journal.pone.0117098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300181/
https://www.ncbi.nlm.nih.gov/pubmed/25603410
http://dx.doi.org/10.1371/journal.pone.0117098

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