Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

PURPOSE: To develop predictive models of apparent solubility (S(app)) of lipophilic drugs in fasted state simulated intestinal fluid (FaSSIF) and aspirated human intestinal fluid (HIF). METHODS: Measured S(app) values in FaSSIF, HIF and phosphate buffer pH 6.5 (PhB(pH6.5)) for 86 lipophilic drugs we...

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Detalles Bibliográficos
Autores principales: Fagerberg, Jonas H., Karlsson, Eva, Ulander, Johan, Hanisch, Gunilla, Bergström, Christel A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300419/
https://www.ncbi.nlm.nih.gov/pubmed/25186438
http://dx.doi.org/10.1007/s11095-014-1487-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300419/
https://www.ncbi.nlm.nih.gov/pubmed/25186438
http://dx.doi.org/10.1007/s11095-014-1487-z

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