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Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid
PURPOSE: To develop predictive models of apparent solubility (S(app)) of lipophilic drugs in fasted state simulated intestinal fluid (FaSSIF) and aspirated human intestinal fluid (HIF). METHODS: Measured S(app) values in FaSSIF, HIF and phosphate buffer pH 6.5 (PhB(pH6.5)) for 86 lipophilic drugs we...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300419/ https://www.ncbi.nlm.nih.gov/pubmed/25186438 http://dx.doi.org/10.1007/s11095-014-1487-z |